James Aramini

James Aramini, Ph.D., is a Research Associate Professor and Biomolecular NMR facility manager at the ASRC Structural Biology Initiative. He was appointed in August of 2015.

Aramini is a structural biologist and spectroscopist, with a particular specialty in nuclear magnetic resonance (NMR) spectroscopy. His scientific interests are focused on applying NMR to important biological problems in the areas of health and human disease, including cancer proteins and complexes, influenza virus proteins and antiviral drug design, DNA binding and DNA repair proteins, and metal ion binding proteins. His research has encompassed using NMR to elucidate the three-dimensional solution structures of proteins and nucleic acids, probe protein:protein complexes and dynamics at interfaces, and investigating metal ion and ligand binding to proteins. His biological NMR interests extend to “exotic” nuclei such 19F NMR of fluorinated proteins and peptides and quadrupolar central transition (QCT) NMR of metal ions in proteins.

Aramini received his B.Sc.Hon. in Chemistry from Simon Fraser University in British Columbia, before obtaining his Ph.D. degree from the University of Calgary in 1994 for his QCT NMR research on metalloproteins with Prof. Hans Vogel. He then pursued a postdoctoral fellowship in nucleic acid NMR with Prof. Markus Germann at Thomas Jefferson University, Philadelphia PA, before joining Prof. Gaetano Montelione at Rutgers University in 2001 as a research assistant professor and staff scientist within the Protein Structure Initiative funded Northeast Structural Genomics consortium.


Protein structure and dynamics using Nuclear Magnetic Resonance spectroscopy.